THE CURRENT PORTRAYAL OF NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING IN A PORTUGUESE TERTIARY CENTER



Enhancing the anticoagulant profile of meizothrombin

Meizothrombin is BIRD an active intermediate generated during the proteolytic activation of prothrombin to thrombin in the penultimate step of the coagulation cascade.Structurally, meizothrombin differs from thrombin because it retains the auxiliary Gla domain and two kringles.Functionally, meizothrombin shares with thrombin the ability to cleave p

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